Wine has four build formats and depending on what build you want, you will have to pay attention to what you install and its format.
The four build types are: WoW64, old WoW64, 64-bit, and 32-bit. 32-bit and 64-bit are self-explanatory, but both WoW64 types need explanation. WoW64 is a compatibility layer created by Microsoft when applications and computers were becoming 64-bit. This layer allows users to emulate 32-bit Windows applications on a 64-bit CPU. For Wine, this has the same premise; it allows you to run both 32-bit and 64-bit Windows apps and games on x86_64. However, there are two WoW64 types.
The first one is the newer and default WoW64 architecture. All you need are 64-bit libraries and both the x86_64 and i686 MinGW-w64 toolchains. The older architecture uses 32-bit libraries to bring the 32-bit support. It is in opposition to a goal the desktop has been moving towards: full 64-bit, leaving 32-bit libraries behind. So the new architecture was developed to satisfy it.
The WoW64 option can be a good choice, and if you go with that route, you won't need MLFS at all, or any 32-bit libraries from this book, unless you want or already have installed Steam. With that, you only need to do the normal installations of each package, and for the MinGW-w64 toolchain, you still have to install both the x86_64 and i686 toolchains.
If you have an issue with the newer WoW64 architecture or trust the older system more, you will then need both the 64-bit and lib32 variants of each package, along with the x86_64 and i686 MinGW-w64 toolchains.
For pure 64-bit, follow the instructions normally and skip the lib32 instructions. When you install the MinGW-w64 toolchain, you can just follow the x86_64 instructions.
For pure 32-bit, follow only the lib32 instructions. When you reach MinGW-w64, follow the i686 instructions. However, for the sake of continuing onto BLFS, it is recommended to do the normal installations as well, save for MinGW-w64. Along with that, Wine may need programs from the given set of packages and this installation method is not tested without the normal 64-bit installations.
GStreamer-Suite-1.26.10: Allows consuming and working with multimedia such as music and videos. Most games and some software work without it, although some will need it for WMA decoding.
sdl2-compat-2.32.62: For input handling and other features.
Vulkan-SDK-1.4.335.0: For Vulkan support.